Orthopedic management of the extremities in patients with Morquio A syndrome.

BackgroundMusculoskeletal involvement in Morquio A syndrome (mucopolysaccharidosis IVA; MPS IVA) contributes significantly to morbidity and mortality. While the spinal manifestations of the disorder have received considerable attention in the literature, there have been few reported studies to date to guide the management of the orthopedic problems associated with the lower and upper extremities.PurposeThe objective was to develop recommendations for the management of the extremities in patients with Morquio A syndrome.MethodsA group of specialists in orthopedics, pediatrics and genetics with experience in the management of Morquio A patients convened to review and discuss current clinical practices and to develop preliminary recommendations. Evidence from the literature was retrieved. Recommendations were further refined until consensus was reached.Results and conclusionsThis present article provides a detailed review and discussion of the lower and upper extremity deformities in Morquio A syndrome and presents recommendations for the assessment and treatment of these complications. Key issues, including the importance of early diagnosis and the implications of medical therapy, are also addressed. The recommendations herein represent an attempt to develop a uniform and practical approach to managing patients with Morquio A syndrome and improving their outcomes

Modeling of activated carbon and coal gasification char absorbents in single-solute and bisolute systems

A mathematical model of fixed-bed adsorption was used to predict the bed response to a sustained step change in influent concentration. The model was employed to compare the performance of different adsorbents in the removal of organics from water and to analyze factors that affect desorption owing to a decrease in influent concentration and to competitive adsorption. Model equations, which considered that film transfer and surface diffusion controlled the adsorption rate, were solved with the technique of orthogonal collocation. Three species, 3,5-dimethylphenol (DMP), 3,5-dichlorophenol (DCP) and rhodamine 6G (R6G), were the single solutes studied, and the two phenols were also examined as a mixture. Four activated carbons and a coal gasification char were the adsorbents studied. The model was used to compare the adsorbents in the removal of DMP, R6G and the bisolute mixtures and equilibrium capacity was found to have a greater influence than kinetics on fixed-bed performance. It was observed that, under conditions approximating a drinking water plant, the time during which the effluent concentration of a desorbed species was higher than the influent concentration was significant (on the order of weeks) whether a reduced influent concentration or competition was responsible for the desorption.U.S. Department of the InteriorU.S. Geological SurveyOpe

Effect of Seeding Method on Bromus Spp. Control with Preplant Applications of Atrazine and Cyanazine in No-till Wheat

Agronom

The Nonlinear Stability of a Heavy Rigid Plate Supported by Flexible Columns

A heavy rigid platform is supported by thin elastic legs. The governing equations for large deformations are formulated and solved numerically by homotopy and quasi-Newton methods. Nonlinear phenomena such as non-uniqueness, catastrophe and hysteresis are found. A global critical load for nonlinear stability is introduced

Total Coal Thickness of the Lower Elkhorn Coal in Eastern Kentucky

This map is one of a series that shows the regional characteristics of the Lower Elkhorn coal. The maps were prepared as part of the U.S. Geological Surveys National Coal Assessment Program, which compiles regional maps and databases that provide a comprehensive assessment of the most important coal beds in the nation. The Lower Elkhorn coal is one of the leading producers in the state of Kentucky and has, in some areas, a reputation as an excellent metallurgical-grade coal. It is known locally as the Pond Creek, Imboden, Path Fork, Blue Gem, Straight Creek, Bruin, or Vires coal bed. This map represents the total coal thickness, minus partings, of the bed for the eastern Kentucky region. It is not a traditional isopach map, because the mineable bed is not composed of the same benches in all areas (Fig. 1). Discontinuities, delineated by facies boundaries on the map, indicate abrupt changes in thickness caused by splitting; discontinuities also occur between areas where entirely different beds in the Lower Elkhorn zone are favored for mining

Coal Resources of the Lower Elkhorn Coal Bed in Eastern Kentucky

This chart is one of a series that shows the regional characteristics of the Lower Elkhorn coal. The maps were prepared as part of the U.S. Geological Survey\u27s Natural Coal Assessment Program, which compiles regional maps and databases that provide a comprehensive assessment of the most important coal beds in the nation. The Lower Elkhorn coal is one of the leading producers in the state of Kentucky and has, in some areas, a reputation as an excellent metallurgical-grade coal. It is known locally as the Pond Creek, Imboden, Path Fork, Blue Gem, Straight Creek, Bruin or Vires coal bed. This chart describes the distribution of data used for the coal assessment, generalized mined-out areas in relation to coal thickness, geologic structure of the bed, and coal-resource estimates

Algorithm XXX: SHEPPACK: Modified Shepard Algorithm for Interpolation of Scattered Multivariate Data

Scattered data interpolation problems arise in many applications. Shepard’s method for constructing a global interpolant by blending local interpolants using local-support weight functions usually creates reasonable approximations. SHEPPACK is a Fortran 95 package containing five versions of the modified Shepard algorithm: quadratic (Fortran 95 translations of Algorithms 660, 661, and 798), cubic (Fortran 95 translation of Algorithm 791), and linear variations of the original Shepard algorithm. An option to the linear Shepard code is a statistically robust fit, intended to be used when the data is known to contain outliers. SHEPPACK also includes a hybrid robust piecewise linear estimation algorithm RIPPLE (residual initiated polynomial-time piecewise linear estimation) intended for data from piecewise linear functions in arbitrary dimension m. The main goal of SHEPPACK is to provide users with a single consistent package containing most existing polynomial variations of Shepard’s algorithm. The algorithms target data of different dimensions. The linear Shepard algorithm, robust linear Shepard algorithm, and RIPPLE are the only algorithms in the package that are applicable to arbitrary dimensional data

Magnetohydrodynamic Flow Past a Porous Rotating Disk In a Circular Magnetic Field

This paper studies the effects of a circular magnetic field on the flow of a conducting fluid about a porous rotating disk. Using modern quasi-Newton and globally convergent homotopy methods, numerical solutions are obtained for a wide range of magentic field strengths, suction and injection velocities and Alfven and disk speeds. Results are presented graphically in terms of three nondimensional parameters. There is excellent agreement with previous work and asymptotic formulas